Nerve Growth Factor is vital to all major systems and organs in the body. Librela suppresses it

HELP! What is happening to my pet?

Nerve growth factor (NGF) plays a critical role anywhere there is a signaling to/from the brain. It is most abundant in the central nervous system, peripheral nervous system, autonomic nervous system, and the development and maintenance of sympathetic and sensory neurons.

Additionally it regulates the immune and endocrine systems and is key to the development, maintenance, and injury repair at the cellular level including organ, muscle, bone, skin and hair.

NGF is integral in the production of red blood cells. NGF circulates throughout the entire body via the blood plasma. It is important for the overall maintenance of homeostasis. Understandably blocking NGF can result in catastrophic disruption and harm to any or all systems and organs.

Librela®/ Beransa® and Solensia® block NGF with a synthetic protein. This is why the array and severity of adverse reactions are so extensive. Their active ingredients, bedinvetmab and frunevetmab, target all systemic NGF, not just the NGF involved in pain signaling of arthritic joints. It intervenes in the signaling of pain, it does not address the cause of pain.

References: https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-239, and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916855/#:~:text=Nerve%20growth%20factor%20(NGF)%20was,the%20endocrine%20and%20immune%20systems and https://www.scientificamerican.com/article/the-nerve-growth-factor/

Sensory nerves are some of the first affected by Librela, Beransa, Solensia.

Sudden loss of one or more sensory perceptions has been frequently reported by pet parents.

How do I get this out of my pet's system? Is there an antidote?

No, there is no antidote.

Librela® is a monoclonal antibody (mAb), it cannot be flushed or detoxed from your pet's system. It exits the system through protein degradation. However, it cannot be said with certainty what it binds to while in the system or the ramifications of that binding.

Librela®, Beransa® and Solensia® were not tested for interactions with other medications (except nSAIDS for 2 weeks) therefore it cannot be definitively stated what will happen when other pharmaceuticals are introduced.

Dr. Josie's recovery protocol

How long does it take to leave their system?

How do I get this out of my pet's system? Is there an antidote?

There is no definitive answer.

A speculative time frame of 30-90 days has been widely circulated. Half-life is a metric with pharmaceutical drugs.

However, because this is not a pharmaceutical drug, rather it belongs to a novel therapeutic category of biologics, it has the potential for triggering the immune system, what is called "immunogencity" .

Half Life estimator

Is this recoverable?

How do I get this out of my pet's system? Is there an antidote?

Is this recoverable?

Short answer: no one can say for certain. Not the vets, not the drug maker, NO ONE. Just as they cannot conclusively say which pets it will help and which it will harm.

Neither can they say it is not recoverable. Therefore: the possibility exists so TRY EVERYTHING until your pet tells you they can no longer battle. You know your pet better than anyone.

Stories that give hope:

"He is improving daily, no more sundowning or dementia like behavior, his eyes are clear again, sleeping through the night and is almost his old self!"

Vet Lessons on Librela® Video

food, supplements & other treatments to help your pet in crisis

What can I do to help my pet?

The best you can do is support their body:

· Minimize chemicals into their system

· Ensure top nutritional intake

· Spring water instead of tap water

· Supplements for specific issues

· Maintain routine and physical activity as much as possible

· Care and comfort

Food, Supplements & Other Treatments

Dog with anorexia, one of the most common effects of Librela® / Beransa® or Solensia®

Dealing with Anorexia

One of the most common, and most traumatic, adverse effects of Librela® / Beransa® or Solensia® is Anorexia. This can leave pet parents feeling distraught because how can you help them if you can't get nutrition into them? Here's what you need to know to deal with this condition.

Help with Anorexia

For large dogs afflicted with paralysis and/or incontinence you'll need a harness to help them

Help lifting large dogs

Paralysis, loss of use of hind end, joint degradation, ataxia, sudden collapse, are all commonly reported effects that require physical assistance for our pets. For help lifting larger pups pet parents have recommended the Help Em Up harness, link below.

Help Em Up Harness

HELP! What is happening to my pet?

How do I get this out of my pet's system? Is there an antidote?

How do I get this out of my pet's system? Is there an antidote?

How do I get this out of my pet's system? Is there an antidote?

How long does it take to leave their system?

How do I get this out of my pet's system? Is there an antidote?

How do I get this out of my pet's system? Is there an antidote?

Is this recoverable?

How do I get this out of my pet's system? Is there an antidote?

Is this recoverable?

What can I do to help my pet?

Dealing with Anorexia

Help lifting large dogs

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